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GeoffPainPhD's avatar

Very interesting thanks. Abca12 gene is also hit by endotoxin.

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Lars Peterson's avatar

In the presentation I'm makining I could have added this paper as further evidence but I didn't want to make it overly long. When I get to the point about the probiotics this will come back but it's an example in my conceptual understanding that various bacteria use the dysbiosis caused by fluoride to increase transformative stress via abca12.

"Pseudomonas Aeruginosa

biofilm, in a ceram-idastin-sensitive manner, also silenced PPARδ via induction of miR-106b. Low PPARδ limited ABCA12 expression resulting in disruption of skin lipid homeostasis. Barrier function of the wound-site was thus compromised"

https://pubmed.ncbi.nlm.nih.gov/35129518/

"

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